TETRAMETHYLENE DIBROMIDE
1,4-Dibromobutane
CAS: 110-52-1
Molecular Formula: C4H8Br2
TETRAMETHYLENE DIBROMIDE - Names and Identifiers
| Name | 1,4-Dibromobutane |
| Synonyms | Dibromobutane 1,4-Dibrombutan 1,4-DIBROMOBUTANE 1,4-Dibromobutane 1,4-dibromo-butan 1,4-dibromo butane 1,4-BUTYLENE BROMIDE TETRAMETHYLENDIBROMID TETRAMETHYLENE BROMIDE tetramethylene bromide 1,4-BUTYLENE DIBROMIDE Tetramethylene dibromide TETRAMETHYLENE DIBROMIDE |
| CAS | 110-52-1 |
| EINECS | 203-775-5 |
| InChI | InChI=1/C4H8Br2/c5-3-1-2-4-6/h1-4H2 |
| InChIKey | ULTHEAFYOOPTTB-UHFFFAOYSA-N |
TETRAMETHYLENE DIBROMIDE - Physico-chemical Properties
| Molecular Formula | C4H8Br2 |
| Molar Mass | 215.91 |
| Density | 1.808 g/mL at 25 °C (lit.) |
| Melting Point | -20 °C (lit.) |
| Boling Point | 63-65 °C/6 mmHg (lit.) |
| Flash Point | >230°F |
| Water Solubility | immiscible |
| Solubility | 0.35g/l |
| Vapor Presure | 1.63 hPa (25 °C) |
| Appearance | Liquid |
| Color | Clear colorless to light yellow-brownish |
| BRN | 1071199 |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong bases. |
| Refractive Index | n20/D 1.519(lit.) |
| Physical and Chemical Properties | Density 1.808 melting point -20°C boiling point 197°C refractive index 1.5176-1.5196 water-soluble immiscible |
| Use | Used in the manufacture of aminophylline, kebiqing, etc. |
TETRAMETHYLENE DIBROMIDE - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 2810 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | EJ7565000 |
| TSCA | Yes |
| HS Code | 29033036 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
TETRAMETHYLENE DIBROMIDE - Nature
Open Data Verified Data
colorless or yellowish liquid. The relative density is 1. 7890(20 ℃). Melting Point -16.53 °c (-20 °c). Boiling point 197~198 degrees C (1.46kPa). Refractive index 5190. Flash point 54 °c. Insoluble in water, soluble in alcohol, ether, chloroform.
Last Update：2025-06-10 22:55:16
TETRAMETHYLENE DIBROMIDE - Preparation Method
Open Data Verified Data
1. Tetrahydrofuran method
2.1,4 butanediol bromination method
Last Update：2022-01-01 10:14:46
TETRAMETHYLENE DIBROMIDE - Application
Open Data Verified Data
It is used for the manufacture of aminophylline, kebiqing, expelling Qingjing, etc.
Last Update：2025-08-19 16:24:40
TETRAMETHYLENE DIBROMIDE - Safety
Open Data Verified Data
Local irritation, high concentration of anesthesia. Packed in 250kg iron drum.
Last Update：2022-01-01 10:14:47
TETRAMETHYLENE DIBROMIDE - Reference Information
| LogP | 3.231 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| properties | 1, 4-dibromobutane is an organic compound, which is a halogenated hydrocarbon, 4-butanediol (or tetrahydrofuran) is obtained by reaction with HBr. It reacts with a secondary amine to obtain a tertiary amine, and the Gemini quaternary ammonium salt is obtained by further reaction. Stable nature, normal temperature and pressure does not decompose. Avoid contact with oxides. There is local irritation, high concentration of anesthesia. |
| storage and transportation method | store in a cool and ventilated warehouse, away from the fire. Keep the container sealed and stored away from the oxidant. Emergency handling equipment and appropriate containment materials should be provided. |
| Use | organic synthesis intermediates, used in the manufacture of aminophylline, kebiqing, quoukujing, etc. used in the manufacture of aminophylline and kebiqing in medicine used in organic synthesis |
| production method | 1. It is derived from tetrahydrofuran by ring opening and bromination. Hydrobromic acid was added to the reaction Pan, tetrahydrofuran was added dropwise under stirring, and sulfuric acid was added dropwise, and the temperature was controlled to be below 50 °c. After completion of the reaction, the mixture was stirred for 1H. The lower solution was separated by cooling, washed with soda ash solution until neutral, dried with anhydrous calcium chloride, and filtered to obtain the finished product. Derived from the bromination of 1, 4-butanediol. Hydrobromic acid was added to the reaction pot, cooled to 10 °c with stirring, and sulfuric acid was added dropwise. After completion of the addition, 1, 4-butanediol was further added dropwise at a temperature not exceeding 15 ° C., and the mixture was stirred for half an hour. Incubation was performed for 6h at 100-110 °c. Cool to room temperature, separate the lower liquid, wash with soda ash solution to neutral. After Dehydration of calcium chloride, 1, 4-dibromobutane was obtained by filtration. |
Last Update：2024-04-09 21:01:54
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